Michael C. Joiner, PhD
IBPRO Co-Principal Investigator
Department of Radiation Oncology
School of Medicine
Wayne State University
Dr. Joiner has specialized in biophysics and experimental radiation oncology using in vitro and in vivo models at both the basic and the translational level. He discovered low-dose hyper-radiosensitivity and the inverse very low dose-rate effect, both processes are major factors influencing the extent and type of molecular signaling and DNA repair following irradiation and can therefore determine the overall survival of cells and tissue toxicity following X-ray exposure. Joiner has spent a large part of his career investigating how clinical radiotherapy can be made more effective using both manipulations of the radiation delivery schedule and also by the addition of chemical or physical modifiers of effect. He therefore has a considerable understanding of how to recognize and quantify radiation effects, the underlying radiobiology and molecular basis of those effects, as well as the medical physics and biophysics of radiation delivery and dosimetry. This broad interest and research experience has enabled him to develop an effective and valued role in educating and mentoring at undergraduate, graduate and post-graduate/professional levels.
Dr. Joiner is joint editor of the textbook “Basic Clinical Radiobiology”; this book is used in training programs worldwide and also to assist in advanced education in radiation sciences. It has also been published in multiple languages.